2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W027555R
    Ethoxyacetic acid (Standard) 627-03-2 98%
    Ethoxyacetic acid is an endogenous metabolite.
    Ethoxyacetic acid (Standard)
  • HY-W028943S
    (E)-3-Methyl-2-hexenoic acid-d5 98%
    (E)-3-Methyl-2-hexenoic acid-d5 ((2E)-3-Methyl-2-hexenoic acid-d5) is a deuterium labeled (E)-3-Methyl-2-hexenoic acid. (E)-3-Methyl-2-hexenoic acid is an axillary odor-related compound.
    (E)-3-Methyl-2-hexenoic acid-d5
  • HY-W037619R
    Pteridine-2,4(1H,3H)-dione (Standard) 487-21-8 98%
    Pteridine-2,4(1H,3H)-dione is an endogenous metabolite.
    Pteridine-2,4(1H,3H)-dione (Standard)
  • HY-W040141R
    L-Arabinitol (Standard) 7643-75-6 99.95%
    L-Arabinitol (Standard) is the analytical standard of L-Arabinitol. This product is intended for research and analytical applications. L-Arabinitol is a potential biomarker for the comsuption of the food products such as sweet potato, deerberry, moth bean, and is also associated with Alzheimer's disease and ribose-5-phosphate isomerase deficiency.
    L-Arabinitol (Standard)
  • HY-W040194R
    Clomazone (Standard) 81777-89-1 98%
    Clomazone (Standard) is the analytical standard of Clomazone (HY-W040194). This product is intended for research and analytical applications. Clomazone is a broad spectrum herbicide, mainly used to control annual broadleaf weeds and grass weeds in various crops such as rice, soybeans, and peanuts. Clomazone inhibits carotenoid biosynthesis, and treated plants show typical "albinism" symptoms due to the destruction of chloroplast membrane structure leading to chlorophyll degradation. Clomazone exhibits multiple toxic effects on non-target organisms, including aquatic lethality, developmental malformations, liver damage, mitochondrial dysfunction, and hematotoxicity.
    Clomazone (Standard)
  • HY-W041019R
    5-Hydroxytryptophol (Standard) 154-02-9 98%
    5-Hydroxytryptophol is a mammalian serotonin metabolite that can be used as a sensitive biomarker for recent alcohol intake. 5-Hydroxytryptophol is formed by alcohol-induced changes in the serotonin metabolic pathway and is excreted in the urine as a glucuronic acid conjugate. 5-Hydroxytryptophol is elevated in urine excretion and can be used clinically to monitor alcohol intake in scenarios such as alcohol relapse.
    5-Hydroxytryptophol (Standard)
  • HY-W042193R
    2-Piperidone (Standard) 675-20-7 98%
    2-Piperidone is an endogenous metabolite. 2-Piperidone is the biomarker for the activity of CYP2E1.
    2-Piperidone (Standard)
  • HY-W044764R
    2-Benzylsuccinic acid (Standard) 884-33-3 98%
    2-Benzylsuccinic acid (DL-Benzylsuccinic acid) is an orally active carboxypeptidase A and Nna1 inhibitor. 2-Benzylsuccinic acid reduces cold hyperalgesia. 2-Benzylsuccinic acid can be used for the researches of neuropathic pain, non-alcoholic steatohepatitis.
    2-Benzylsuccinic acid (Standard)
  • HY-W045271R
    Imidazole-5-propionic acid (Standard) 1074-59-5 98%
    Imidazole-5-propionic acid is a histidine metabolite.
    Imidazole-5-propionic acid (Standard)
  • HY-W048838R
    Acetyl-L-lysine (Standard) 1946-82-3
    Acetyl-L-lysine is an acetylated form of the amino acid L-lysine. Acetyl-L-lysine can participate in protein acylation processes, affecting protein functions such as stability and enzyme activity.
    Acetyl-L-lysine (Standard)
  • HY-W050044R
    L-Azetidine-2-carboxylic acid (Standard) 2133-34-8 98%
    L-Azetidine-2-carboxylic acid is a proline analog. L-Azetidine-2-carboxylic acid upregulates the lipid autophagy marker LC3-II via activation of the PERK pathway. L-Azetidine-2-carboxylic acid increases pro-apoptotic BAX protein. L-Azetidine-2-carboxylic acid induces ATF6 cleavage and upregulates phosphorylated eIF2α levels. L-Azetidine-2-carboxylic acid induces ER stress, inducing protein misfolding and aggregation. L-Azetidine-2-carboxylic acid shows teratogenic, pro-inflammatory and pro-apoptotic effects.
    L-Azetidine-2-carboxylic acid (Standard)
  • HY-W051287R
    4-Hydroxy-2-butanone (Standard) 590-90-9 98%
    4-Hydroxy-2-butanone (Standard) is the analytical standard of 4-Hydroxy-2-butanone (HY-W051287). This product is intended for research and analytical applications. 4-Hydroxy-2-butanone is a free volatile component of glycoside precursors in wax gourd.
    4-Hydroxy-2-butanone (Standard)
  • HY-W068212R
    16-Hydroxyhexadecanoic acid (Standard) 506-13-8 98%
    16-Hydroxyhexadecanoic acid (Juniperic acid) is an ester product.
    16-Hydroxyhexadecanoic acid (Standard)
  • HY-W068771R
    (E)-3-(4-Methoxyphenyl)acrylic acid (Standard) 943-89-5 98%
    (E)-3-(4-Methoxyphenyl)acrylic acid (compound 3) is isolated from Arachis hypogaea, Scrophularia buergeriana Miquel, Aquilegia vulgaris, Anigozanthos preissii and so on. (E)-3-(4-Methoxyphenyl)acrylic acid shows significant hepatoprotective activity, anti-amnesic, cognition-enhancing activity, antihyperglycemic, and neuroprotective activities.
    (E)-3-(4-Methoxyphenyl)acrylic acid (Standard)
  • HY-W094475E
    Magnesium sulfate heptahydrate, United States Pharmacopeia (USP) Reference Standard 10034-99-8 98%
    Magnesium sulfate heptahydrate, United States Pharmacopeia (USP) Reference Standard (Epsom salts (Pharmaceutical primary standard, USP)) is currently the anticonvulsant of choice for the prevention and control of eclamptic fits and is also widely used as a tocolytic agent.
    Magnesium sulfate heptahydrate, United States Pharmacopeia (USP) Reference Standard
  • HY-W094847R
    Eicosane (Standard) 112-95-8
    Eicosane (Standard) is the analytical standard of Eicosane. This product is intended for research and analytical applications. Eicosane is an ester product.
    Eicosane (Standard)
  • HY-W096159R
    D-Biotinol (Standard) 53906-36-8 98%
    D-Biotinol (Standard) is the analytical standard of D-Biotinol (HY-W096159). This product is intended for research and analytical applications. D-Biotinol is an orally effective alcohol analogue of D-Biotin (HY-B0511). D-Biotinol can replace D-biotin to restore the biotin deficiency induced by egg whites in rats. D-Biotinol can be used for the study of biotin deficiency disorders.
    D-Biotinol (Standard)
  • HY-W097625R
    6-Methoxyflavone (Standard) 26964-24-9 98%
    6-Methoxyflavone (Standard) is the analytical standard of 6-Methoxyflavone (HY-W097625). This product is intended for research and analytical applications. 6-Methoxyflavone is an orally active methoxyflavone. 6-Methoxyflavone suppresses neuroinflammation in microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling. 6-Methoxyflavone induces S-phase arrest through the CCNA2/CDK2/p21CIP1 signaling pathway and activates the PERK/EIF2a/ATF4/CHOP pathway in HeLa cells. 6-Methoxyflavone acts as a Flumazenil (HY-B0009)-insensitive positive allosteric modulator at human recombinant α1β2γ2L and α2β2γ2L GABAα receptors. 6-Methoxyflavone inhibits NFAT Translocation into the nucleus and suppresses T cell activation. 6-Methoxyflavone partially restores chronic ethanol-induced behavioral deficits in mice. 6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression. 6-Methoxyflavone can be used for the study of cancer, inflammation and neurological diseases.
    6-Methoxyflavone (Standard)
  • HY-W099331R
    Monoethylglycinexylidide hydrochloride (Standard) 7729-94-4
    Benfuracarb (Standard) is the analytical standard of Benfuracarb. This product is intended for research and analytical applications. Benfuracarb is a broad-spectrum carbamate insecticide with crop protection activity. Benfuracarb is used to control springtails, aphids, and other pests, typically on sugar beet crops. Benfuracarb exhibits toxicity to humans and aquatic organisms. Benfuracarb exposure to zebrafish embryos resulted in a reduction in the body length of zebrafish larvae. Superoxide dismutase (SOD) activity was significantly increased after Benfuracarb treatment. Benfuracarb also interfered with the transcriptional levels of marker genes associated with early embryonic development.
    Monoethylglycinexylidide hydrochloride (Standard)
  • HY-W099602R
    Dodecane (Standard) 112-40-3 98%
    Dodecane (Standard) is the analytical standard of Dodecane. This product is intended for research and analytical applications. Dodecane (Ba 51-090453) is an ester product. Dodecane is an aliphatic hydrocarbon. Dodecane can result in a high TNF-α expression and transepidermal waterloss (TEWL).
    Dodecane (Standard)
Cat. No. Product Name / Synonyms Application Reactivity